Erectile dysfunction: Comparison of efficacy and side effects

Sildenafil is a medication used in the management and treatment of erectile dysfunction and pulmonary arterial hypertension. It is in the phosphodiesterase-5 inhibitor (PDE5-I) class of medications. This activity describes the indications, actions, adverse effects, and contraindications of sildenafil as an agent in the clinical setting. Knowledge therein is critical for appropriate healthcare PAH phosphodiesterase-5 (PDE-5 inhibitors) are medications used to treat pulmonary arterial hypertension (PAH). Learn about how they work, usages, side effects, and a list of drugs. The main reported side effects of PDE5i are headaches, dizziness, blushing, nasal congestion, dyspepsia, and visual changes. The most common visual side effects are photophobia, cyanopsia, and haze. Most of the visual effects can be reversed weeks after stopping use of the medication. pde5 inhibitor side effects The occurrence of side effects, or adverse drug reactions (ADRs), with PDE5 inhibitors depends on the dose and type of agent. Headache is a very common ADR, occurring in Several side effects are associated with all three of the currently available PDE-5 inhibitors namely, headache, flushing, nasal congestion, and dyspepsia.Headache, flushing, and nasal congestion are vasodilatory effects and reflect dilation (increased opening) of blood vessels in the head, face, skin of the chest, and nasal mucosa, respectively.

The phosphodiesterase type 5 (PDE5) inhibitors cause vasodilation in the penis and lung by blocking the breakdown of cyclic guanosine monophosphate (cGMP) which results in prolongation of the action of mediators

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